肠道微生物特征的初步分析 儿童 阻塞性睡眠呼吸暂停 缺血症综合征
Zhihui Wang1,2, Luting Zhou1, Yanyu He1
1Department of Respiration, Children's Hospital of Soochow University, Suzhou, China.
Frontiers in neurology
|December 1, 2025
概括
患有阻塞性睡眠呼吸暂停-呼吸暂停综合征 (OSAHS) 的儿童表现出改变的肠道微生物组. 特定的肠道细菌与多睡眠学 (PSG) 指标相关,尽管微生物组的变化对OSAHS的诊断预测有限.
科学领域:
- 微生物组研究的研究.
- 儿科睡眠药物 儿童睡眠药物
- 胃肠病学 胃肠病学
背景情况:
- 阻塞性睡眠呼吸暂停-呼吸暂停综合征 (OSAHS) 在儿童中很普遍.
- 人们越来越认识到肠道微生物在OSAHS病理生理学中的作用.
- 了解儿科OSAHS的肠道微生物组变化对于潜在的治疗点至关重要.
研究的目的:
- 在患有OSAHS的儿童中描述肠道微生物组的变化.
- 探索肠道微生物群组成和多睡眠学 (PSG) 结果在儿科OSAHS之间的关系.
主要方法:
- 16S rRNA高通量测序用于分析患有OSAHS,原发性打和对照儿童的便样本.
- 评估了肠道微生物群的多样性 (α和β) 和组成.
- 在肠道微生物群和PSG参数之间进行了相关性分析.
主要成果:
- 在OSAHS和对照组之间观察到肠道微生物群多样性和组成的显著差异.
- 随着OSAHS的严重程度的增加,Firmicutes/Bacteroidetes的比率也增加了.
- 特定的属 (Akkermansia,Dialister,Escherichia-Shigella,Faecalibacterium) 与睡眠效率和氧和度等PSG指标显示了相关性.
结论:
- 儿科OSAHS与肠道微生物组合的微妙变化有关.
- 虽然Firmicutes/Bacteroidetes比率对OSAHS诊断具有有限的预测价值,但特定的肠道属与关键的PSG指标相关.
- 肠道微生物群可能在OSAHS病理生理学中发挥作用,需要进一步调查.
更多相关视频
07:54Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
20.5K
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
10.8K
相关概念视频
Sleep Apnea
452
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
452
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.1K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.1K
Anatomy of the Intestines
86.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
86.6K
