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Updated: Jan 9, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
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表观遗传学分析揭示了关键的超级增强器网络,这些网络驱动HPV阳性HNSCC的瘤发生

Fernando T Zamuner1, Spencer S Chan2,3, Michael D Kessler4,5

  • 1Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

iScience
|December 1, 2025
PubMed
概括

人类乳头瘤病毒阳性头支状细胞癌 (HPV+ HNSCC) 呈现出独特的表观遗传失调. 以BRD4抑制为目标的超级增强剂通过抑制瘤性途径显示出治疗潜力.

关键词:
生物信息学是一种生物信息学.癌症 癌症 癌症 癌症表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.分子网络分子网络.

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