在代谢后腹手术患者的便calprotectin水平:一个回顾性研究
Fenna M M Beeren1,2, Britt Roosenboom1, Marcel B W Spanier1
1Department of Gastroenterology and Hepatology, Rijnstate Hospital, Arnhem, The Netherlands.
Inflammatory intestinal diseases
|December 1, 2025
概括
便calprotectin (FCP) 的最佳切割界限对于腹腔外科手术后的患者是59.5μg/g. 然而,标准的50μg/g截止值仍然适用于临床使用,因为差异很小,Youden值很低.
科学领域:
- 胃肠病学 胃肠病学
- 临床生物标志物 临床生物标志物
- 外科手术的结果
背景情况:
- 便calprotectin (FCP) 是检测胃肠道炎症和区分刺激性肠综合征和炎症性肠病 (IBD) 的关键生物标志物.
- 代谢性减肥手术 (MBSs) 显著改变胃肠道生理学,可能会影响标准FCP截止值的解释.
- 在接受MBS的患者中,已建立的FCP值的适用性需要调查,以确保准确的诊断效用.
研究的目的:
- 确定最佳的FCP截止值,以确定MBS后患者的相关结肠镜检测结果.
- 为了评估FCP水平和结肠镜检查结果,在MBS后的患者队列中.
- 根据人口和手术因素进行子组分析,以了解FCP变异性.
主要方法:
- 340名接受MBS和随后的FCP测试 (2000-2024) 的患者的回顾性分析.
- 排除手术前IBD的患者.
- 接收器操作特征 (ROC) 曲线分析,以根据结肠镜检查结果确定最佳的FCP截止值.
主要成果:
- 所有患者的FCP水平中位数为51μg/g;对于进行结肠镜检查的人来说 (n=124),它是61μg/g.
- 在有或没有相关发现 (IBD,恶性病) 的患者之间没有发现FCP水平的显著差异 (p=0.101).
- 经过ROC分析,FCP的最佳切线为59.5μg/g (AUC:0.653),但敏感性低 (64.6%) 和特异性低 (63.4%).
结论:
- 在MBS后的患者中,最佳的FCP截止值建议为59.5μg/g.
- 鉴于低的尤登指数和与标准50μg/g截止值的最小差异,保持标准值在临床上被认为更为实用.
- 可能需要进一步的研究来完善FCP解释在MBS后独特的生理上下文.
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