尿液中的重金属混合物与美国成年人中过活性膀风险之间的关联:一个横截面研究
Zhenzhen Liu1,2, Zikai Guo3, Husong Su4
1Department of Gynecology and Obstetrics, Affiliated Hospital of Zunyi, Zunyi, China.
Frontiers in public health
|December 1, 2025
概括
同时接触,,和等有毒金属会增加过活膀 (OAB) 的风险. 尿路中的可以提供保护. 结合金属暴露带来了严重的健康风险.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 暴露于有毒金属与不利的人类健康影响有关.
- 关于同时暴露于金属对过度活性膀 (OAB) 的影响,存在知识差距.
研究的目的:
- 调查重金属同时暴露与成人OAB患病率之间的关联.
- 评估尿金属对OAB风险的单独和综合影响.
主要方法:
- 利用了来自7719名成年人的国家健康和营养检查调查 (NHANES) 数据.
- 采用加权定量和回归,贝叶斯内核机器回归 (BKMR) 和g计算模型.
- 进行了受限制的立方脊柱回归来分析剂量反应关系.
主要成果:
- 尿中的高,,和与较高的OAB风险有关.
- 尿中的酸显示出对OAB的保护作用.
- 同时接触多种金属显著增加了OAB风险,特别是在年轻/中年成人和酒精消费者中.
结论:
- 同时接触有毒金属混合物会显著增加患过度活性膀 (OAB) 的风险.
- 特定的金属组合和相互作用有助于OAB的发展.
- 需要进行前性研究来进一步验证这些发现.
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