在外周动脉疾病中,C反应性蛋白与白蛋白的比率
Pandit Bagus Tri Saputra1,2, Dinda Dwi Purwati3, Pratista Oktafia3
1Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya East Java, Indonesia.
Open medicine (Warsaw, Poland)
|December 1, 2025
概括
反应性C蛋白与白蛋白比率 (CAR) 可以预测经过内血管治疗 (EVT) 的外周动脉疾病 (PAD) 患者的死亡率和截肢率. 高的CAR水平表明这些不良结果的风险明显增加.
科学领域:
- 血管医学 血管医学
- 生物标志物 生物标志物
- 预测指标的预测指标
背景情况:
- 周围动脉疾病 (PAD) 是一种严重的血管疾病.
- 内血管治疗 (EVT) 是PAD的常见治疗方法.
- 在接受EVT的PAD患者中预测不良结果至关重要.
研究的目的:
- 评估C反应性蛋白与白蛋白比率 (CAR) 的预后性能.
- 评估CAR在接受EVT的PAD患者中预测死亡率和截肢的能力.
主要方法:
- 对多个数据库和灰色文献进行系统的文献搜索.
- 五项观察性研究的元分析,包括1451名受试者.
- 基于个别研究的最佳截止值来定义高和低CAR.
主要成果:
- 术前高CAR与增加的死亡率 (RR 3.11) 和截肢 (RR 3.62) 有关.
- 卡尔表现出良好的预后性能,AUC为0.75的死亡率和0.85的截肢.
- 对CAR的负预测值很高 (死亡率为90.5%,截肢为97.8%).
结论:
- C-反应性蛋白与白蛋白比率 (CAR) 显示出作为预后生物标志物的潜力.
- 在接受EVT的PAD患者中,CAR可以预测死亡率和截肢率.
相关概念视频
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Cardiac myocytes produce these hormones in response to ventricular stretching...
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01:30Peripheral Artery Disease I: Introduction
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01:27Peripheral Artery Disease III: Interprofessional Care
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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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