大麻使用和慢性鼻炎和鼻外科手术的风险
Austin J Lee1, Michael W Liu1, David C Kaelber2,3,4
1Case Western Reserve University School of Medicine Cleveland Ohio USA.
Laryngoscope investigative otolaryngology
|December 1, 2025
概括
大麻使用与新发慢性鼻炎 (CRS) 的风险降低以及需要功能性内镜外科手术 (FESS) 相关. 这些发现表明大麻在CRS发育和进展方面具有潜在的保护作用.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 大麻使用与喘等呼吸系统疾病之间的关联已有证据,但其对慢性鼻炎 (CRS) 的影响仍然不太清楚.
- 调查大麻消费和CRS之间的关系对于理解其更广泛的健康影响至关重要.
研究的目的:
- 探索大麻使用与新发慢性鼻炎 (CRS) 发生率之间的关联.
- 检查大麻使用与与鼻息肉 (CRSwNP) 发生慢性鼻炎之间的关系.
- 评估大麻使用对CRS患者功能性内镜外科手术 (FESS) 发生率的影响.
主要方法:
- 使用TriNetX分析研究网络进行的一项回顾性队列研究,分析了2012年1月至2019年12月的电子健康记录.
- 成年患者 (≥18岁) 被分为大麻使用者和非使用者群体,用于比较分析的倾向性得分匹配.
- 主要结局包括新发病的CRS和CRSwNP诊断的相对风险以及最初使用大麻诊断后1,2年和5年的FESS.
主要成果:
- 大麻使用与诊断后1,2,5年 (aRR从0.83到0.87) 显著降低未指定的CRS风险有关.
- 在大麻使用者和非使用者之间,没有观察到与鼻息肉 (CRSwNP) 发生慢性鼻炎的风险显著差异.
- 在先前存在的CRS患者中,大麻使用者在1,2,5年 (aRR从0.64到0.69) 经历功能性内镜外科手术 (FESS) 的风险较低.
结论:
- 大麻使用与新发性CRS风险的统计显著下降以及FESS的需要有关.
- 这些发现表明,大麻在CRS的背景下具有潜在的保护作用,因此需要对潜在机制进行进一步调查.
- 建议进行额外的研究,以阐明大麻使用和CRS结果之间观察到的关联中涉及的因果关系和生物途径.
相关概念视频
Epistaxis
504
Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
504
Drugs Used in Upper Respiratory Disorders: Overview
604
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
604
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
653
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
653
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
744
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
744
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
929
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
929
Chronic Pharyngitis
10.6K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
10.6K


