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Updated: Jan 9, 2026

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells
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IGF1R通过调节DNA-PKcs介导的DNA损伤修复来促进辐射诱导的HSCs激活

Jiguo Lin1, Gang Zhao1, Jie Feng1

  • 1NHC Key Laboratory of Radiobiology, College of Public Health, Jilin University, Changchun, China.

Frontiers in cell and developmental biology
|December 1, 2025
PubMed
概括

电离辐射通过胰岛素样生长因子1受体 (IGF1R) 和DNA-PKcs相互作用促进DNA修复,从而激活肝细胞. 抑制这种途径可以防止辐射诱导的肝纤维化.

关键词:
修复DNA损伤的修复取决于DNA的蛋白激酶催化子单元.肝脏的恒星细胞.胰岛素样生长因子1受体电离辐射辐射的电离辐射.

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