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补充黄素在西斯普拉丁诱导的急性损伤中表现出脏保护作用
Mingkang Zhang1,2,3, Yazhi Wang4, Xiujuan Wang1
1School of Pharmacy Lanzhou University Lanzhou China.
Food science & nutrition
|December 1, 2025
概括
黄素是一种食补充剂,可以通过恢复线粒体功能和减少氧化应激来防止西斯普拉丁诱导的毒性. 这项研究表明黄素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 药理学 药理学是指药理学的学科.
- 线粒体生物学 线粒体生物学
背景情况:
- 西斯是用于固体瘤的广泛使用的化疗剂.
- 西斯普拉丁诱导的毒性是显著的剂量限制副作用.
- 目前,没有有效的治疗方法可以预防或减轻西斯的毒性.
研究的目的:
- 为了研究黄素对西斯普拉丁诱导的脏损伤的保护作用.
- 为了阐明黄素脏保护作用的潜在机制,在体外和体内.
主要方法:
- 在体外实验中评估了黄素对暴露于西斯的管状上皮细胞的影响.
- 在体内研究评估了黄素补充剂对线粒体动力学,氧化应激,亡和运输体表达的影响.
- 分析了包括AMPK/PGC-1α/Sirt3,Nrf2/Keap1和Bax/Bcl2/Caspase-3在内的关键信号通路.
主要成果:
- 西斯普拉丁诱导管损伤,线粒体功能障碍,活性氧物种 (ROS) 增加和亡.
- 黄素治疗通过AMPK/PGC-1α/Sirt3通路恢复了线粒体平衡.
- 黄素通过Nrf2/Keap1和Bax/Bcl2/Caspase-3通路缓解氧化应激和亡,并调节运输体以减少毒素积累.
结论:
- 黄素有效地减轻了西斯普拉丁诱导的毒性.
- 黄素的保护作用通过恢复线粒体功能,减少氧化应激和亡以及调节运输体表达来调节.
- 黄素显示出作为治疗剂的潜力,可以预防或治疗西斯普拉丁诱导的损伤.
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