咖啡消费与发生胃肠道疾病的风险:一项大型前性队列研究
Shenxuan Zhou1, Fulan Hu2, Zhiping Long3
1Department of Epidemiology, School of Public Health Nantong University Nantong Jiangsu China.
Food science & nutrition
|December 1, 2025
概括
饮用未加糖咖啡,特别是每天2 - 4杯,与胃肠道疾病 (GID) 的风险降低有关. 这一发现支持咖啡的发现.
科学领域:
- 胃肠病学 胃肠病学
- 营养流行病学 营养流行病学
- 预防医学 预防医学
背景情况:
- 咖啡消费对胃肠道疾病 (GID) 的影响尚未完全理解,特别是关于甜味剂的使用.
- 现有的关于咖啡和GID的研究缺乏明确性,特别是在不同类型的甜味剂方面.
- 甜味剂在咖啡与GID相关性的作用需要进一步研究.
研究的目的:
- 调查咖啡消费模式 (未加糖,天然加糖,人工加糖) 与发生胃肠道疾病 (GID) 的风险之间的关联.
- 根据遗传倾向,探索咖啡摄入量是否会改变基于遗传倾向的GID风险.
- 检查可能受到咖啡消费和甜味剂类型影响的特定GID.
主要方法:
- 对147263名没有先前存在GID的参与者进行前性队列研究.
- 咖啡摄入量通过24小时饮食回忆评估,并按甜味剂类型分类.
- 通过医疗记录识别的事件GID;用于估计危险比率 (HRs) 和95%置信区间 (CI) 的Cox比例危险模型.
- 多基因风险评分 (PRS) 评估遗传倾向;进行子组和敏感性分析.
主要成果:
- 未加糖的咖啡显示了一种剂量依赖的,U形的关联与较低的GID风险 (最低在2-4杯/天;HR:0.84).
- 观察到未加糖咖啡对GERD,胃炎/十二指肠炎和胆道疾病有保护作用.
- 自然甜味咖啡的益处有限,而人工甜味剂与GID风险有不一致的关联.
- 未加糖的咖啡减轻了对GIDs的遗传倾向,显示出对分泌和肝硬化有显著的添加相互作用.
结论:
- 没有加糖的咖啡消费与患上胃肠道疾病 (GID) 的风险降低有关.
- 研究结果表明,未加糖的咖啡可能对消化系统健康有益,可以在饮食建议中考虑.
- 需要进一步的研究来阐明这些关联背后的机制,并确认在不同人群中发现的结果.
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