柳茶通过激活PI3K/Akt路径来降低AQP3的调节和恢复肠道微生物群来缓解便秘
Wenxin Yu1,2, Jing Xue1, Zehua Yang1
1School of Chinese Materia Medica Guangdong Pharmaceutical University Guangzhou China.
Food science & nutrition
|December 1, 2025
概括
柳茶通过激活PI3K/Akt通路和调节肠道微生物群来缓解便秘. 这种深茶增加了便中的水含量,并减少了便秘的老鼠的炎症.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
背景情况:
- 由于现代生活方式和饮食变化,便秘的患病率正在增加.
- 由水素 (AQPs) 影响的异常肠道水运输是便秘的关键因素.
- 暗茶,包括Liupao茶,已经显示出缓解便秘的潜力,但其机制需要进一步研究.
研究的目的:
- 为了研究Liupao茶缓解便秘的机制.
- 使用网络药理学预测潜在的目标和途径.
- 在大鼠模型中评估柳茶对肠道水运输,炎症和肠道微生物群的影响.
主要方法:
- 网络药理学和UPLC-MS/MS用于目标预测.
- 建立一个多因素诱导便秘的老鼠模型.
- 评估结肠病理 (HE染色),炎症因子 (免疫组织化学),肠道微生物群 (16S rRNA测序),AQP3表达 (RT-qPCR) 和PI3K/Akt通路激活 (西部斑点).
主要成果:
- 在便秘的老鼠中,柳茶增加了便中的水含量,并降低了结肠和胃炎症标志物 (TNF-α,IL-6,IL-1β).
- 柳茶增强了Akt酸化,并降低了水素3 (AQP3) 的表达.
- 柳茶调节了肠道微生物组成,与改善的氨基酸代谢相关.
结论:
- 柳茶通过激活PI3K/Akt通路,抑制AQP3表达和调节肠道微生物群来改善氨基酸代谢来缓解便秘.
- 柳茶通过多目标和多途径机制显示出对便秘的治疗潜力.
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