肠道微生物群和休时间的饮食指数 身体活动:对高血压风险的潜在联合保护性影响
Jiaxin Wang1, Xinyi Lu1,2,3, Yongting Zhao4
1Academician Collaborative Laboratory for Basic Research and Translation of Chronic Diseases, Central Laboratories The First Affiliated Hospital of Jinan University, Jinan University Guangzhou China.
Food science & nutrition
|December 1, 2025
概括
肠道微生物群饮食指数 (DI-GM) 的高分数和足够的休时间体育活动 (LTPA) 独立降低高血压风险. 结合良好的肠道健康饮食和定期炼,可以增强对高血压的保护.
科学领域:
- 心血管健康 心血管健康
- 肠道微生物组研究研究
- 营养流行病学 营养流行病学
背景情况:
- 新兴研究将肠道微生物组代谢物和内皮功能障碍与高血压联系起来.
- 通过肠道微生物群的饮食指数 (DI-GM) 评估的饮食质量会影响肠道微生物群的健康.
- 众所周知,休时间体育活动 (LTPA) 可以降低血压,但其与DI-GM对高血压的联合作用尚不清楚.
研究的目的:
- 调查DI-GM和LTPA对患高血压风险的单独和综合影响.
- 探索DI-GM,LTPA和高血压之间的剂量反应关系.
- 通过使用大型,具有全国代表性的数据集来分析人口层面的关联.
主要方法:
- 从NHANES (2007-2020年) 中对27643名美国成年人的横截面分析.
- 使用加权后勤回归和限制立方线 (RCS) 来评估关联.
- DI-GM分数和LTPA模式 (强度,频率,规律性) 是关键变量,定期活动定义为>2天/周.
主要成果:
- 更高的DI-GM得分和更高的每周LTPA显著与更低的高血压概率有关.
- 对DI-GM和LTPA都观察到一个剂量依赖的反向关系.
- 个人DI-GM>4和足够的LTPA (≥150分钟/周或常规模式) 显示最低的高血压概率.
结论:
- 高DI-GM得分 (≥6) 和足够的LTPA (≥150分钟/周) 独立地与降低高血压风险有关.
- 最佳的DI-GM和适当的LTPA的组合显示出对高血压的协同保护作用.
- 建议进行进一步的前性研究,以确定因果关系并探索潜在的机制.
相关概念视频
Lifestyle Factors and Health
395
Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
395
Atherosclerosis III: Management
296
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
296
Hypertension IV: Drug Therapy and Lifestyle Modifications
578
Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
578
Factors affecting Blood pressure
6.3K
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
Physiological Factors:
6.3K
Hypertension II: Pathophysiology
708
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
708
Hypertension III: Clinical Manifestations and Diagnostic Studies
443
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
443


