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菌 (Enterococcus faecium B13) 通过调节肠道微生物群和代谢物影响小鼠的生长
Fan Luo1, Jiajun Wu1, Shumin Wang1
1College of Animal and Veterinary Sciences Southwest Minzu University Chengdu China.
Food science & nutrition
|December 1, 2025
概括
Enterococcus faecium B13的使用增强了小鼠的体重增加和降低了血清甘油三. 肠道微生物群分析显示,Firmicutes/Bacteroidetes比率和Alloprevotella等特定属的变化,这表明了益生菌机制.
科学领域:
- 微生物学 微生物学
- 动物科学动物科学
- 代谢学 代谢学 代谢学
背景情况:
- 肠道微生物群显著影响动物的生长性能.
- 以前已经证明,菌B13可促进小猪的生长.
- 维生素B13促进生长的基本机制需要阐明.
研究的目的:
- 研究Enterococcus faecium B13促进雄性小鼠生长的机制.
- 分析B13给药对生长性能,肠道微生物群组成和代谢物概况的影响.
- 确定关键的微生物参与者和涉及B13介导生长促进的代谢途径.
主要方法:
- 在雄性小鼠中,口服输液注射Enterococcus faecium B13.
- 监测生长表现和血清甘油三水平.
- 使用测序对肠道微生物群组成进行分析.
- 使用液态染色体质谱仪 (LC-MS) 识别差异性代谢物.
- 微生物属和代谢物之间的相关性分析.
主要成果:
- 维生素B13的使用表明体重增加的趋势,并且血清甘油三酸显著降低.
- 观察到肠道微生物组成的显著变化,包括增加了Firmicutes/Bacteroidetes比率.
- 特定的属,特别是Alloprevotella,被确定为差异丰富且与关键代谢途径相关.
- 代谢分析揭示了诸如阿拉基酸和阿尔金因代谢等途径的显著变化.
结论:
- 菌B13显示出作为促进生长的益生菌剂的潜力.
- 肠道细菌Alloprevotella似乎在B13介导的增长促进作用中发挥着至关重要的作用.
- B13通过调节特定的肠道微生物群落及其代谢输出,影响宿主代谢.
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