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优化通过蛋白装饰的纳米结构脂质载体通过microRNA传递

Ivana Ruseska1, Amina Tucak-Smajić2, Ivan Vidaković3

  • 1Department of Pharmaceutical technology and Biopharmacy, Institute of Pharmaceutical Sciences, University of Graz, Universitätsplatz 1, 8010 Graz, Austria.

International journal of pharmaceutics: X
|December 1, 2025
PubMed
概括

microRNA-27a在治疗肥胖症方面表现有前途,但面临着交付挑战. 用人血清白蛋白 (HSA) 覆盖miRNA载的阴离子纳米结构脂质载体 (cNLC) 产生了albplex,增强了潜在的抗肥胖疗法的稳定性和细胞吸收.

关键词:
细胞吸收的时间人类血清专素的人类血清专素脂质纳米颗粒是一种纳米粒子.蛋白质冠状病毒的冠状病毒这是一个小RNARNA.

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.