基于PLGA的药物输送系统的释放机制:一项审查
1Univ. Lille, Inserm, CHU Lille, U1008, F-59000 Lille, France.
International journal of pharmaceutics: X
|December 1, 2025
概括
药物输送系统显示复杂的释放模式. 了解胀和个体微粒子的行为是优化可控释放配方的关键.
科学领域:
- 生物材料科学 生物材料科学
- 制药科学 制药科学
- 聚合物化学 聚合物化学
背景情况:
- 聚乳-同-甘油酸 (PLGA) 微粒和植入物对于亲腔控制药物输送至关重要.
- 目前对PLGA系统中药物释放机制的理解有限,阻碍了产品优化和大规模制造.
- 复杂的物理化学过程控制药物释放,通常导致三相模式:初始爆发,零顺序和最终快速释放.
研究的目的:
- 提供关于基于PLGA的亲肠控制药物递送系统中药物释放机制的当前知识的概述.
- 强调配方,加工和环境因素对药物释放动态的影响.
- 提高人们对经常被忽视的方面的认识,特别是系统胀和微粒集成平均数据的潜在误导性.
主要方法:
- 文献综述和对PLGA药物递送系统的当前知识的综合.
- 分析影响药物释放的因素,包括成分,几何,制造和环境条件.
- 讨论各种涉及的物理化学现象,如水透,药物溶解,扩散,聚合物胀,降解和透效应.
主要成果:
- 药物释放是多因素的,受系统特性和环境的影响,导致复杂的三相释放配置文件.
- 关键现象包括水透,药物溶解,通过聚合物矩阵/孔径扩散,聚合物胀,降解和透效应.
- 实质性的系统胀被假设为第三个释放阶段的主要驱动因素,微粒的集体分析可以掩盖单个粒子的行为.
结论:
- 优化PLGA药物输送系统需要深入了解复杂的多因素释放机制.
- 系统胀和个体微粒子行为是控制释放的关键,经常被忽视的因素.
- 一个个案例的评估是必不可少的,考虑到每个PLGA交付系统的具体配方,制造和预期应用.
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