针治疗糖尿病病:机制,临床证据和未来的前景
Jing Yue1,2, Jinhao Guo2, Xinru Wang1
1College of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Frontiers in endocrinology
|December 1, 2025
概括
针通过调节炎症和代谢途径,显示出糖尿病病 (DN) 的潜力. 组合疗法可能会带来更大的益处,但需要更多高质量的试验来证实疗效和安全性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 综合医学是一个整体医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病病 (DN) 是末期病的主要原因,目前的治疗方法往往无法充分管理.
- 针正在作为DN的补充治疗方法进行研究.
- 了解针的机制和DN的临床影响至关重要.
研究的目的:
- 从2010-2025年审查糖尿病病 (DN) 针的临床前和临床证据.
- 总结DN中针的作用机制,干预模型,结局和针的安全性.
- 评估针作为DN的辅助治疗的潜在作用.
主要方法:
- 对DN针的临床前 (动物) 和临床 (人类) 研究进行系统审查.
- 对单独检查针,与中医,与西方医学,或作为三重治疗的研究进行分析.
- 评估报告的免疫-炎症,代谢,抗氧化,细胞和微循环通路受到针的影响.
主要成果:
- 针调节关键通路 (例如,HMGB1/NLRP3/NF-κB,SIRT1/AMPK/PGC-1α,自) 并增强DN模型中的抗氧化防御.
- 临床研究表明,针可以减少蛋白尿,改善功能 (eGFR) 和代谢控制.
- 联合针疗法可以提供更快或更广泛的益处,具有良好的安全性.
结论:
- 针表现出多个目标,对糖尿病病有益的互补作用.
- 它可以与DN管理的标准护理集成.
- 进一步高质量,大规模的随机对照试验是必要的,以验证发现和标准化协议.
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