离子交联pH响应的相互透的多糖网络水凝片,用于针对结肠的布德索尼德输送
Pallobi Dutta1, Kaushik Mukherjee1, Tapan Kumar Giri1
1Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
Drug development and industrial pharmacy
|December 1, 2025
概括
新的半互穿透聚合物网络 (半IPN) 水凝片有效地将布德索尼德 (BUD) 输送到结肠. 这些响应pH的片剂保护药物在上部胃肠道,确保在结肠中有针对性的释放.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 药物运输 药物运输 药物运输
背景情况:
- 针对结肠的药物输送旨在提高局部疾病的治疗疗效.
- 布德索尼德 (BUD) 是一种强效的抗炎药物,用于炎症性肠病.
- 现有的配方可能面临着在上部胃肠道中药物过早释放的挑战.
研究的目的:
- 开发新的pH响应的水凝片,用于结肠特异性布德森化物 (BUD) 的输送.
- 为了研究相互透的多糖网络的潜力,以控制药物释放.
- 优化水凝配方,以增强药物保护和有针对性的释放.
主要方法:
- 制备pH响应单网络,相互透的聚合物网络 (IPN) 和半相互透的聚合物网络 (半IPN) 的水凝片.
- 使用了天然的多糖类,如 guar gum (GG) 和 carboxymethyl 纤维素 (CMC).
- 与 (Ca2+) 离子进行离子交联,以创建水凝矩阵.
主要成果:
- 单网络和IPN水凝在最初的5小时内显示药物释放的控制不足.
- 半IPN水凝矩阵片显示出有利的胀,侵蚀和药物释放特征.
- 优化的半IPN片 (GG:CMC 1:1) 在4小时内没有BUD释放,在5小时后只有9%的释放.
结论:
- 开发的半IPN水凝矩阵适合于结肠特异性的布德索尼德的输送.
- 这种配方有效地保护BUD免于在胃和小肠中过早释放.
- 半IPN水凝的pH响应性促进了药物在结肠中的向作用.
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