在食物过敏时吃东西
Yue Jennifer Du1, Jessica C Guo2, Julia E M Upton3
1Internal Medicine, DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
概括
早期和持续口服接触过敏性食物可以预防食物过敏 (FA) 的发展,即使有诸如湿疹等危险因素. 目前的治疗包括量身定制的预防和免疫疗法,生物药物有助于耐受性,并可能导致持续缓解.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 过敏研究 研究过敏
背景情况:
- 食物过敏 (FA) 是一个日益严重的全球健康问题,影响患者和医疗保健系统.
- 双过敏原假设认为,早期皮肤暴露会增加敏感性,而早期口服摄入会促进耐受性.
- 了解FA的发展和管理至关重要,因为它对生活质量产生重大影响.
研究的目的:
- 审查当前对食物过敏 (FA) 发展和管理策略的理解.
- 探索早期口服食物暴露在预防FA中的作用.
- 讨论不断发展的治疗方法,包括免疫疗法和生物药物.
主要方法:
- 对当前关于食物过敏 (FA) 病原和治疗的研究进行文献综述.
- 关于暴露路径的双重过敏原假设的分析.
- 对FA的现有和新兴治疗干预措施的概述.
主要成果:
- 早期和持续的口服摄入过敏性食物可以预防FA,取代其他风险因素,如湿疹.
- 量身定制的避免策略,如使用非化的牛奶或蛋产品,现在是常见的.
- 食品免疫疗法,包括各种途径和剂量,越来越多,生物药物增强安全性和耐受性.
结论:
- 早期口服食物暴露是预防食物过敏 (FA) 的关键因素.
- 食品免疫疗法和生物药物为管理FA,减少反应性,并可能实现缓解提供了有希望的途径.
- 治疗时间,特别是在年轻人IgE形成较低的时期,可以优化缓解结果,而老年患者可以从增加的反应值中受益.
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