在Bordetella物种中获得的抗微生物耐药性基因:全球基因组分析
Biao Tang1, Xiaohe Hu1, Yu Song1
1Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, Hangzhou, University of Chinese Academy of Sciences, China.
The Journal of antimicrobial chemotherapy
|December 1, 2025
概括
在非百日咳的Bordetella物种中发现了抗菌素耐药性基因,特别是B. bronchiseptica. 这些耐药菌株显示国际传播,突出显示需要持续监测.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 波德特拉属包括重要的病原体,如B. pertussis.
- 抗微生物耐药性 (AMR) 是一种越来越令人担忧的细菌病原体.
- 获得的抗微生物耐药性基因 (ARG) 很少在非百日咳的Bordetella物种中报告.
研究的目的:
- 在非百日咳的Bordetella物种中表征抗菌素耐药性基因 (ARG).
- 为了研究耐药波尔代特拉菌株的基因组多样性和传播模式.
主要方法:
- 获取并组装了746个非B. 百日咳 Bordetella基因组来自NCBI. 百日咳 百日咳 Bordetella基因组来自NCBI.
- 使用Abricate,ResFinder和BLAST识别了ARG;使用Easyfig.可视化了基因组背景.
- 进行了核心基因组SNP基因组和贝叶斯聚类,以界定血统和量化传播.
主要成果:
- 在B. bronchiseptica (96),B. trematum (7),和B. avium (2) 中确定了105个ARG.
- 观察到十种不同的ARG类型,它们对硫胺,四环素,氨基糖化物和β-乳酸盐具有耐药性.
- B. bronchiseptica系2表现出最多样化的多药耐药分离物,频繁的国际和交叉宿主传播.
结论:
- 在Bordetella物种中监测AMR至关重要.
- 这些发现突出了耐药波尔代特拉菌株传播的潜力.
- 积极的监测可以帮助缓解抗菌素耐药性的传播.
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