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在绝经后的妇女中,参与者特征与乳房外细胞质感变异之间的关联
Sarah J Nyante1, Yukie Kajita1, Xianming Tan2
1University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
概括
绝经后妇女的乳房图片对细胞质地与年龄和BMI等因素有关,但与生殖史无关. 未知的乳腺癌风险机制可能会影响纹理模式.
科学领域:
- 放射学和成像科学 放射学和成像科学
- 瘤学研究研究
- 流行病学 流行病学
背景情况:
- 乳房图片上的帕伦基马质地是已知的乳腺癌风险预测指标.
- 影响哺乳镜纹理变异性的因素尚未得到充分了解.
- 这项研究调查了女性乳腺癌风险因素和乳房镜纹理之间的关系.
研究的目的:
- 评估乳房镜纹理特征与绝经后妇女临床/流行病学风险因素之间的关联.
- 为了确定哪些因素导致乳腺对酶体质感的变化.
- 探索潜在的未知乳腺癌风险机制,与乳腺镜纹理相关.
主要方法:
- 在2020年10月至2022年7月期间,招募了305名绝经后妇女.
- 344个纹理特征从二维数字乳房影像中提取出来,并使用主要组件分析和集群分析进行分析.
- 使用统计测试和多项逻辑回归来评估纹理集群和参与者特征之间的关联.
主要成果:
- 参与者被分为三个不同的乳房图纹理组.
- 纹理组因年龄,BMI,种族,更年期以来的时间和乳腺密度指标 (BI-RADS,百分比和密度区域) 显著不同.
- 参与者的特征占了乳腺造影纹理特征变化的32%.
结论:
- 绝经后妇女的乳房图纹理受到随时间变化的因素的影响,例如BMI和乳房尺寸.
- 纹理模式似乎不太受生殖事件的影响,例如平价或第一个出生时的年龄.
- 解释的有限变异性表明,未知或未经研究的乳腺癌风险机制与纹理模式有关.
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