早期新殖民者在发育中的小肠中持久的辅助微生物组具有持久的功能意义
Ori Furman1,2, Gil Sorek1,2, Sarah Moraïs1,2
1Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.
The ISME journal
|December 1, 2025
概括
早期的乳头微生物组,包括新型微生物,持续到成年期,影响宿主发育. 这些早期殖民者充当生态系统工程师,塑造了皮.
科学领域:
- 微生物组研究的研究.
- 鲁门生态学 鲁门生态
- 主体-微生物相互作用
背景情况:
- 体微生物组组合对于宿主发育至关重要.
- 早期的微生物群落可以产生持久的影响.
- 了解早期殖民者的持久性和功能是关键.
研究的目的:
- 为了研究小牛早期的小肠微生物群的长期持久性和功能.
- 识别新型微生物种类及其在发育中的作用.
- 探索早期殖民者到成年时代的生态和功能相关性.
主要方法:
- 从出生到三岁的小牛的高分辨率纵向元基因组学.
- 重建元基因组组装基因组 (MAG).
- 时间聚类和代谢网络分析.
主要成果:
- 重建了2873个高质量的MAG,包括517个新型基因组.
- 新型的辅助微生物组被确定具有不同的功能 (环境传感,营养生物合成,VFA代谢).
- 早期微生物群落持续到成年期,影响与宿主相关的功能.
结论:
- 早期的殖民者在罗马尼亚充当"生态系统工程师".
- 早期的微生物组是一个结构化的,功能相关的社区,而不仅仅是一个短暂的阶段.
- 这些发现对理解宿主发育和生态系统动态有意义.
相关概念视频
Bacterial Flora of the Large Intestine
1.5K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.5K
Anatomy of the Intestines
86.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
86.6K
Bacterial Phylum Firmicutes
881
Firmicutes is a diverse phylum of Gram-positive bacteria characterized by a low GC content in their genomes. This phylum includes organisms with monoderm or diderm cell envelopes, highlighting a complex evolutionary history. Firmicutes comprises several major orders, including Lactobacillales, Clostridiales, and Bacillales, which exhibit remarkable diversity in their morphology, metabolism, and ecological roles.The order Lactobacillales includes lactic acid bacteria, which are fermentative...
881
Other Unique Bacteria
394
Magnetic bacteria exhibit a directed movement called magnetotaxis, driven by structures called magnetosomes. These magnetosomes consist of chains of magnetic particles made of either magnetite (Fe₃O₄) or greigite (Fe₃S₄) and are organized in a linear conformation by a protein scaffold within invaginations of the cell membrane. The bacteria align along the north–south magnetic field lines, much like a compass needle. They are typically microaerophilic or anaerobic...
394
Microbial Nutrition
1.0K
Organisms exhibit remarkable metabolic diversity, categorized based on how they acquire energy and carbon. These strategies enable survival in various ecological niches and are essential for maintaining energy flow and nutrient cycling within ecosystems.Energy and Carbon SourcesOrganisms are classified as phototrophs or chemotrophs based on energy acquisition. Phototrophs use light as their energy source, while chemotrophs rely on oxidizing chemical compounds. Further differentiation arises...
1.0K


