肠病和肝脏疾病在常见可变免疫缺陷中的预后影响:回顾性队列研究
José Miranda-Bautista1,2, Helena Martínez-Lozano1,2, Marisa Di Natale3
1Department of Gastroenterology and Hepatology, Hospital General Universitario Gregorio Marañón, Madrid (Spain).
胃肠道和肝脏问题在常见变性免疫缺陷 (CVID) 中很常见. 与CVID相关的肠道病变增加了胃肠道感染的风险,而肝脏疾病增加了CVID患者的死亡风险.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 胃肠道 (GI) 和肝脏表现影响高达三分之一的常见变性免疫缺陷 (CVID) 患者.
- 在CVID中肠病和肝病的预后意义需要进一步评估.
研究的目的:
- 评估CVID相关肠病 (CVID-E) 和CVID相关肝脏病 (CVID-L) 对患者结局的预后影响.
- 在CVID患者中确定死亡率,胃肠道感染和胃肠道癌症的风险因素,包括胃肠道和肝脏表现.
主要方法:
- 从1990年到2023年,对112名成年CVID患者进行了回顾性研究.
- 基于客观的临床,内镜,组织学,放射学或血液动力学发现,诊断CVID-E和CVID-L.
- 分析预后结果,包括存活率,肠道感染和肠道癌症,并确定风险因素.
主要成果:
- 在CVID患者中,有29.2%患有CVID-E,25.8%患有CVID-L.
- CVID-E与更高的肝脏参与率,胃肠道感染和胃肠道癌症有关.
- CVID-E独立预测胃肠道感染;CVID-L和诊断时的年龄预测死亡率.
结论:
- 胃肠道和肝脏表现在CVID中很常见,并且经常同时发生.
- 这些条件显著影响CVID疾病的发展过程,增加肠道感染,恶性瘤和死亡的风险.
- 在CVID管理中,CVID-E和CVID-L是关键的预后因素.
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