大动脉病理中的计算流体动力学:当前的应用,挑战和未来的前景
Augusto F Sanches1, Zicheng Wan2,3,4, Natasha Hasemaki2
1Department of Vascular Surgery, University Hospital LMU Munich, Munich, Germany - augusto.sanches@med.uni-muenchen.de.
The Journal of cardiovascular surgery
|December 1, 2025
概括
计算流体动力学 (CFD) 通过分析复杂的大动脉弧血动力学来帮助血管外科手术. CFD量化了流动干扰,改善了手术规划和大动脉门疾病患者的治疗结果.
科学领域:
- 血管外科 血管外科
- 生物医学工程 生物医学工程
- 医疗成像医学成像
背景情况:
- 大动脉呈现出影响血液动力学的解剖学复杂性.
- 大动脉门的血液流动受损与疾病进展和手术并发症有关.
研究的目的:
- 审查计算机流体动力学 (CFD) 在大动脉门病理中的当前应用.
- 突出CFD在血管外科的进展,局限性和未来方向.
主要方法:
- 审查关于CFD在大动脉门疾病中的应用现有文献.
- 来自CFD模拟的血液动力学生物标志物的分析.
- 讨论临床翻译的挑战和潜在的解决方案.
主要成果:
- CFD量化了与大动脉形病理相关的血液动力学生物标志物 (例如,壁切应力,振荡切指数).
- 差价合约有助于术前规划,器件设计和术后监测.
- 临床翻译受到成像质量,工作流程复杂性和缺乏标准化的限制.
结论:
- CFD显示出对大动脉的精密血管手术有很大的潜力.
- 未来的方向包括工作流程自动化,机器学习和实时模拟用于临床采用.
- 标准化和前性验证对于将CFD纳入常规临床实践至关重要.
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