氧化与sufentanil对脊柱PVP手术的疼痛治疗有什么不同?
Jing Zhao1, Shanshan Yu2, Jingfei Deng2
1Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Suqian City, China.
概括
与sufentanil相比,oxycodone有效地管理皮肤通脊椎造形术 (PVP) 期间的疼痛,提供更好的止痛和血液动力学稳定性. 这项研究突出了氧化的作用.
科学领域:
- 麻醉学 麻醉学
- 疼痛管理 疼痛管理
- 脊柱外科手术 脊柱外科手术
背景情况:
- 麻醉选择对于皮肤穿透脊椎造形术 (PVP) 至关重要,影响疼痛缓解,镇静,副作用和患者满意度.
- 氧化和苏芬坦尼尔是常见的止痛药,但它们在PVP疼痛管理中的比较有效性尚未得到充分证实.
研究的目的:
- 为了研究氧化在脊椎皮肤通脊椎造形术 (PVP) 疼痛管理中的临床有效性.
- 为了比较PVP中的氧化和sufentanil之间的止痛作用,镇静水平,不良反应和患者满意度.
主要方法:
- 一项对100名接受脊柱PVP的患者进行的回顾性研究,分为氧化 (50) 和苏芬坦尼尔 (50) 组.
- 麻醉方案:氧化组接受了普罗波和氧化; 苏芬坦尼尔组接受了普罗波和苏芬坦尼尔.
- 术内参数,术后疼痛评分 (VAS),血液动力学稳定性和不良事件的比较.
主要成果:
- 氧化组需要更少的额外普罗波,并且在手术期间身体运动较少.
- 手术后的疼痛评分 (VAS) 在手术后的第1天和第3天在氧化组显着较低.
- 氧化组在术后表现出更好的血液动力稳定性,SBP,DBP,HR和SpO2的变化较低.
结论:
- 氧化二对PVP的手术内疼痛管理是有效的,改善了镇痛效果并保持了血液动力学稳定性.
- 与PVP程序中的sufentanil相比,氧化提供了良好的安全性和优越的止痛效果.
- 这些发现支持促进氧化用于皮肤穿透脊椎造形术的疼痛管理.
相关概念视频
Opioid Analgesics: Synthetic and Semisynthetic Opioids
888
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
888
Analgesia and Pain Management
1.4K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.4K
Local Anesthetics: Clinical Application as Epidural Anesthesia
672
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
672
Local Anesthetics: Clinical Application as Spinal Anesthesia
1.3K
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
1.3K
Opioid Analgesics: Morphine and Other Natural Cogeners
813
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
813
Parenteral Anesthetics: Overview
546
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
546


