在COVID-19大流行后,全球百日咳的发生率
Andrew Gorringe1, Breeze Cavell1, Frank Beard2
1UK Health Security Agency, Porton Down, Salisbury, United Kingdom.
JAMA network open
|December 1, 2025
概括
全球范围内百日咳疫情正在上升,特别是在青少年中,尽管COVID-19流行病的低点. 需要新的疫苗来对抗 Bordetella pertussis,包括耐药菌株,并减少传播.
科学领域:
- 传染性疾病 传染性疾病
- 细菌学 细菌学是一门学科.
- 疫苗学 疫苗学 疫苗学
背景情况:
- 百日咳是由 Bordetella pertussis 引起的,是一种严重的呼吸系统疾病,对婴儿特别危险.
- 最近的全球百日咳发病率在COVID-19大流行期间下降,但自那以后急剧增加,特别是在青少年中.
- 在大流行前,一些国家观察到,Bordetella pertussis菌株缺乏无细胞疫苗抗原pertactin,尽管最近的隔离物表达了它.
研究的目的:
- 总结最近 Bordetella pertussis 发病率和特征的趋势.
- 为了突出宏类耐药菌株的出现.
- 强调需要改进百日咳疫苗接种策略和开发新型疫苗的需要.
主要方法:
- 来自国际波德氏菌协会在线研讨会 (2024年11月12日) 的数据综合.
- 对报告的百日咳发病率和参与国家的百日咳 Bordetella 隔离特征的审查.
- 分析疫苗抗原表达和抗生素耐药性的趋势.
主要成果:
- 大多数国家在COVID-19大流行期间和之后立即报告了非常低的百日咳发病率.
- 自疫情爆发以来,许多国家经历了严重的百日咳疫情,特别是在青少年中.
- 几个国家报告说,抗宏类药物耐药的Bordetella pertussis分离物增加.
结论:
- 百日咳的复苏需要维持和增加孕妇,婴儿和儿童的疫苗接种范围.
- 新出现的 Bordetella pertussis 菌株具有抗原表达变化和抗生素耐药性,这对目前的疫苗构成了挑战.
- 开发新的百日咳疫苗,提供更广泛的防治疾病,感染和传播的发展至关重要.
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