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在长时间的APTT中检测氨酸污染,用氨酸耐药溶液检测

Elizabeth Crosby¹, Thomas Exner², Manita Dangol²

¹Welsh Blood Service, Aneurin Bevan UHB Pathology, Grange University Hospital, Cardiff Metropolitan University, Wales, UK.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

|December 1, 2025

概括

一种新的试剂,Antihepca HRRS,在激活的部分血栓形成时间 (APTT) 测试中有效中和未分离的肝素 (UFH) 干扰. 这种溶液有助于在临床实验室中区分真正的凝血病态与肝素污染.

科学领域:

临床化学临床化学
血液学血液学血液学
实验室医学实验室医学

背景情况:

激活的部分血栓形成时间 (APTT) 对于凝血评估至关重要.
长时间的APTT可能源于病理或未分离氨酸 (UFH) 污染.
区分真正的病理与肝素干扰对于患者护理至关重要.

研究的目的:

为了评估Antihepca HRRS (AHCa) 的有效性,一种抗肝素的反化溶液 (HRRS),在中和肝素干扰的APTT试验中.
为了评估AHCa对APTT的影响,在肝化和非肝化患者样本中得出结果.
为了确定UFH的AHC a的中和极限.

主要方法:

在Sysmex CN-6000和Stago Start Max分析仪上使用AHC a HRRS和标准CaCl2进行APTT测试.
样本包括33个肝化,41个非肝化和30个随机延长APTT患者的血.
用氨酸的血来确定AHC a.的UFH中和极限.

主要成果:

在具有UFH高达0.6 IU/mL的样本中,AHCa HRRS纠正了延长的APTT.
在肝素化样本中,AHC将APTT降低到40秒以下,简化了报告.
在30个长期APTT样本中,AHCa纠正了8个,表明肝素,而20个表明其他原因.

结论:

在APTT测试中,AHCa HRRS有效中和UFH干扰.
在非化样本中,AHCa对APTT结果的影响最小,保持准确性.
在临床实验室中,AHCa为识别肝素污染提供了一个切实可行的替代方案.

关键词:

高级代表代表,最高代表代表.这是一种抗的抗肝药.乙氨酸中和的中和化长时间的APTT.没有分离的肝素 (UFH)

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