与疗法相关的甲状腺变化模仿甲状腺恶性病:一个诊断陷
Irene Y Chen1, Adel K El-Naggar2
1Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
International journal of surgical pathology
|December 1, 2025
概括
疗法可能会引起类似癌症的甲状腺炎,导致误诊和不必要的手术. 识别的使用方法
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 是双相情绪障碍的关键情绪稳定剂,但已知与甲状腺功能障碍,特别是甲状腺功能低下有关.
- 诱导的甲状腺炎虽然很少见,但可以呈现出显著的组织形态变化,可能被误认为是恶性瘤.
- 准确诊断甲状腺结节对于避免过度治疗至关重要,特别是在有过使用史的患者中.
研究的目的:
- 报告甲状腺结节的病例,最初被误诊为高度甲状腺癌,原因是严重的组织形态变化.
- 在专家审查后,将甲状腺结节重新归类为长期治疗的阳效应.
- 强调考虑疗法在模仿恶性瘤的甲状腺病变的差异诊断中的重要性.
主要方法:
- 来自外部机构的甲状腺结节的组织病理学发现的审查.
- 对临床病史的分析,包括长期的疗法.
- 观察到的组织学特征与2022年世界卫生组织甲状腺癌分类标准的比较.
主要成果:
- 甲状腺结节,最初被诊断为高度癌症,被重新分类为相关甲状腺炎.
- 组织学特征如纤维化,炎症和激增等模仿恶性瘤,但缺乏像线粒活性这样的关键指标.
- 由于对初始活检和带切除结果的误解,患者进行了不必要的完成甲状腺切除术.
结论:
- 诱导的甲状腺炎可能呈现出与甲状腺癌非常相似的特征,需要仔细的临床病理相关性.
- 详细的患者病史,特别是关于的使用,对于诊断甲状腺病变和预防过度治疗至关重要.
- 这一案例强调了需要对阳性性甲状腺变化和甲状腺瘤诊断标准的不断变化的认识.
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