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过度饮酒会减弱人类中枢动脉对西格玛受体-1连接体的响应能力

Patricia Zamora Diaz^1,2, Tram Q Le^1,2, Laura Hurtado Osorio^1,2

¹Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.

American journal of physiology. Heart and circulatory physiology

|December 1, 2025

概括

西格玛受体会影响人体动脉收缩,但大量饮酒会降低西格玛受体-1的表达,从而损害这种效应. 这突出了酒精.

科学领域:

药理学和生理学药理学和生理学
血管生物学血管生物学
神经科学是一个神经科学.

背景情况:

西格玛受体与血压调节有关.
西格玛受体,动脉和酒精消费之间的相互作用尚未得到充分理解.

研究的目的:

为了研究西格玛受体调节对人类中枢动脉中烯酸诱导的收缩的影响.
探索器官捐赠者的酒精使用史对这种相互作用的影响.
为了检查与酒精消费相关的西格玛受体-1表达.

主要方法:

电线肌图被用来评估烯诱导的动脉收缩.
实验中使用西格玛受体激动剂 (PRE-084) 和对抗剂 (BD-1047,SM-21) 进行了实验.
自动毛细管电泳分析了西格玛受体-1蛋白水平.

主要成果:

西格玛受体激动剂PRE-084将非/轻度和中度饮酒者,但不是重度饮酒者在动脉中的基度-反应曲线向下移动.
西格玛受体-1抗剂BD-1047在非/轻度和中度饮酒者中向上移动曲线,但不是重度饮酒者.
与其他群体相比,沉重饮酒者的动脉中西格玛受体-1蛋白水平明显较低.

结论:

人体动脉中的西格玛受体可能会促进放松,但这种功能因大量饮酒而受到损害.
在大量饮酒者中降低了西格玛受体-1表达,损害了其调节动脉收缩的能力.
西格玛受体-1在人体动脉律中起作用,由酒精使用调节.

关键词:

动脉收缩是一种动脉收缩.动脉收缩动脉收缩人类动脉的人类动脉.西格玛受体的受体

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