编程死亡连接体1蛋白在头部和部状细胞癌及其临床病理相关物的表达
Abdullah Ahmad Bader1,2, Manal A Abbas1, Maher A Sughayer3
1Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman, Jordan.
概括
高编程死亡干1 (PD-L1) 表达在头部和部状细胞癌 (HNSCC) 中很常见. 然而,PD-L1水平并没有显著影响HNSCC患者的整体存活率.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 免疫逃避是癌症的一个关键特征.
- 编程死亡配体1 (PD-L1) 结合免疫细胞上的PD1抑制了抗瘤反应.
- PD-L1的表达可能有所不同,并且可能具有预后价值.
研究的目的:
- 为了评估PD-L1表达在头部和部状细胞癌 (HNSCC).
- 研究PD-L1表达和临床病理特征之间的关联.
- 确定PD-L1对HNSCC总生存时间的影响.
主要方法:
- 免疫组织化学 (IHC) 用于评估63个HNSCC瘤组织中的PD-L1表达.
- 应用了组合阳性得分 (CPS) 截止值 (≥1,≥5,≥20).
- 统计分析将PD-L1与临床病理因素和整体存活率相关联.
主要成果:
- 在85.7% (CPS≥1),60.3% (CPS≥5) 和52.3% (CPS≥20) 的HNSCC病例中检测到PD-L1表达.
- 在PD-L1表达和大多数临床病理特征之间没有发现显著的相关性,除了烟草使用 (CPS≥20).
- PD-L1表达没有显著影响4年总生存率,年龄,分化,瘤大小或淋巴血管入侵也没有.
结论:
- 头部和部状细胞癌经常表现出高PD-L1表达.
- 在HNSCC中,PD-L1蛋白表达不是总生存的显著预后因素.
- 进一步的研究可能会探索其他影响生存的因素,如女性性别,复发和围神经入侵.
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