在以色列原住民和移民族裔人口中,CKD的比较模式
Yael Einbinder1,2, Tzipi Hornik-Lurie3, Keren Cohen-Hagai1,2
1Department of Nephrology and Hypertension, Meir Medical Center, Kfar Saba, Israel.
Clinical journal of the American Society of Nephrology : CJASN
|December 1, 2025
概括
慢性病 (CKD) 的进展在以色列各族群之间存在显著差异. 埃塞俄比亚移民在年轻人中表现出更快的CKD进展,而本地阿拉伯人面临着所有年龄段的最高风险.
科学领域:
- 科和公共卫生
- 慢性病的流行病学 慢性病的流行病学
- 医疗保健中的种族差异
背景情况:
- 慢性病 (CKD) 是一个主要的全球健康问题,显著影响发病率和死亡率.
- 现有的研究表明,在不同种族的人群中,CKD流行率和进展率存在相当大的差异.
- 了解这些种族差异对于有针对性的公共卫生干预和公平的医疗保健服务至关重要.
研究的目的:
- 调查和比较慢性病 (CKD) 在以色列不同种族群体的流行率和进展情况.
- 为了确定特定的民族群体在CKD发展和不良进展的风险较高.
- 分析人口因素和传统风险因素对不同种族队列中CKD结果的影响.
主要方法:
- 追溯纵向队列研究,使用来自以色列大型医疗保健提供商Clalit Health Services的电子病历.
- 包括超过160万会员,包括埃塞俄比亚移民,前苏联移民,本土出生的阿拉伯人和本土出生的犹太人.
- 根据估计的淋巴膜过率 (eGFR) 降低 (≥50%),开始替代疗法或死亡率评估CKD进展情况.
主要成果:
- 埃塞俄比亚移民的CKD患病率较低,但在50岁以下的人群中CKD进展更快 (HR 1.47).
- 阿拉伯本土人口的BMI和糖尿病患病率较高,同时在所有年龄组中存在显著EGFR下降的最大风险 (HR1.75).
- 年轻的埃塞俄比亚人显示风险增加和加速eGFR下降,独立于传统的风险因素,突出独特的疾病途径.
结论:
- 在以色列人口中,CKD流行和进展存在显著的种族差异,需要量身定制的临床和公共卫生策略.
- 阿拉伯本土人口面临不成比例的CKD进展风险,与更高的肥胖和糖尿病率有关.
- 年轻的埃塞俄比亚移民表现出加快CKD进展的明显模式,需要进一步调查传统风险因素之外的潜在机制.
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