阴茎癌治疗及其精神病学后果:全国性的分析
Reza Lahiji1, William Luke1, Elizabeth Chu1
1Department of Urology, Emory University School of Medicine, Atlanta, Georgia.
Urology practice
|December 1, 2025
概括
阴茎癌患者面临很高的心理健康疾病 (MHD) 风险,特别是在彻底手术后和伴随疾病. 早期的心理健康支持对于幸存者至关重要,解决护理方面的差异.
科学领域:
- 在瘤学瘤学.
- 心理健康 心理健康
- 医疗保健服务研究 医疗服务研究
背景情况:
- 阴茎癌患者容易患上精神健康问题,如抑郁和焦虑.
- 对于诊断和治疗后的心理健康结果,人口层面的数据有限.
研究的目的:
- 调查阴茎癌诊断和治疗后新发精神健康疾病 (MHD) 的发生率和预测因素.
- 利用全国代表性的医疗保健索赔数据分析心理健康结果.
主要方法:
- 从2009年到2023年对MarketScan商业索赔 (MCCD) 和医疗保险补充数据库 (MSD) 的回顾性分析.
- 包括患有阴茎癌的18岁以上患者,不包括那些事先患有MHD的患者.
- 分类治疗 (根本性,部分性,局部性,局部切除) 并使用多变量Cox模型来确定36个月内新发MHD (严重抑郁症,泛性焦虑症) 的预测因素.
主要成果:
- 14.5% (MCCD) 和14.1% (MSD) 的患者发生了MHD.
- 在MCCD中,彻底切除阴茎切除术 (HR 3.33),查尔森并发症指数 (CCI) 2 (HR 1.74) 和CCI 3+ (HR 2.45) 预测增加了MHD风险.
- 第三个四分位数中的年龄在MCCD中具有保护性 (HR 0.47);预测因素在MCCD和MSD队列之间有所不同.
结论:
- 阴茎癌患者的MHD发病率很高,特别是在彻底手术和并发症后.
- 阴茎癌治疗和MHD之间的关系在商业和Medicare补充保险队伍之间有所不同.
- 幸存者模式必须包括心理健康支持,并解决获取差异.
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