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Updated: Jan 9, 2026

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对于dMMR/MSI-H局部晚期直肠癌患者的新辅助免疫疗法:消除100%临床完整反应范式的神秘性

Federica Marmorino1,2, Federica Morano3, Maria Anna Canciello4

  • 1Unit of Medical Oncology, Azienda Ospedaliera Universitaria Pisana, Pisa 56126, Italy.

The oncologist
|December 1, 2025
PubMed
概括

多斯塔利马布在局部晚期直肠癌 (LARC) 具有不匹配修复缺陷 (dMMR) /微卫星不稳定性高 (MSI-H) 瘤中提供100%的临床完整响应 (cCR) 率,可能消除了化疗和手术的需要. 这份报告详细介绍了三例在多达利利马布治疗期间出现疾病进展的病例.

关键词:
提供了可靠的服务.局部先进的直肠癌 局部先进的直肠癌微卫星的不稳定性很高.不匹配 维修 缺陷 缺陷新辅助免疫疗法新辅助免疫疗法

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