访问到访问的血糖变化与2型糖尿病患者的肺功能变量和肺功能障碍有关
Yi-Hua Wu1,2,3, Chia-Ing Li3,4, Chiu-Shong Liu3,5
1Center for Digestive Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
在2型糖尿病 (T2DM) 中的血糖变化 (GV) 与肺功能减弱有关. 较高的GV,用标准偏差和变化系数来衡量,预测T2DM患者的肺功能障碍.
科学领域:
- 内分泌学 在内分泌学.
- 肺部病理学 肺部病理学
- 生物标志物 生物标志物
背景情况:
- 血糖变化 (GV) 是一种新兴的生物标志物,用于2型糖尿病 (T2DM) 的血糖控制.
- 脊髓炎和肺功能障碍之间的关联需要进一步评估.
研究的目的:
- 评估T2DM患者的GV和肺功能障碍之间的关联.
主要方法:
- 一项后续研究分析了3,108名T2DM患者 (2001-2020) 的数据.
- 使用快速血葡萄糖 (FPG) 指标计算GV:标准偏差 (SD),平均真实变化率 (ARV),变化系数 (CV) 和独立于平均值的变化率 (VIM).
- 肺功能障碍被定义为1秒内强迫呼吸量 (FEV1) /强迫生命能力 (FVC) 比率<0.70;使用多变量回归模型.
主要成果:
- FPG-SD,FPG-CV,FPG-AVR和FPG-VIM与FEV1负相关,预测FEV1的%和FVC.
- 较高的FPG-CV,FPG-SD和FPG-AVR三位数与肺功能障碍的几率增加显著相关.
- GV测量 (CV,SD,VIM) 与肺功能障碍和大多数肺功能变量有关,不包括FEV1/FVC比率.
结论:
- 血糖变化,特别是通过CV和SD测量时,与T2DM患者的肺功能障碍有关.
- 在T2DM患者中,GV可以作为一个有价值的生物标志物,用于预测和评估T2DM患者肺功能障碍.
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