在患有卵巢储量减小的患者中,将京中药融入试管婴儿/ICSI-ET周期
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Updated: Jan 9, 2026

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Fertility Preservation in Patients with Severe Ovarian Dysfunction
Published on: March 25, 2021
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Xuefei Yuan1, Chen Du2, Cheng Zhang3
1College of Life Sciences, Hebei Normal University; Center for Reproductive Medicine of Changhai Hospital, Naval Medical University.
Journal of visualized experiments : JoVE
|December 1, 2025
概括
京中药 (YZD) 在接受试管婴儿的卵巢储备减少 (DOR) 的妇女中改善了卵巢功能和胚胎发育. 这种传统的中国草药配方可以提高生育结果,并支持其在辅助生殖中的使用.
科学领域:
- 生殖医学 生殖医学
- 传统中国医药 传统中国医药
- 卵巢生物学 卵巢生物学
背景情况:
- 卵巢储备减少 (DOR) 影响了辅助生殖技术 (ART) 中的生育结果.
- 京中药 (YZD) 是一种传统的中国草药配方,显示出改善卵巢功能的潜力.
- 有限的标准化临床证据表明YZD在DOR患者中的有效性.
研究的目的:
- 评估YZD在接受IVF/ICSI-ET的DOR妇女的临床疗效.
- 调查YZD对卵巢功能在早产卵巢衰竭 (POF) 的小鼠模型中的机械效应.
- 为整合YZD到ART循环提供一个标准化的协议.
主要方法:
- 一项临床试验比较单独的GnRH抗剂协议与DOR患者的YZD.
- 在老鼠中诱导POF,然后对YZD进行治疗,并评估雌激素周期性,激素水平和卵巢组织学.
- 电子显微镜分析自细胞形成和卵巢细胞中的脂质积累.
主要成果:
- 与对照组相比,YZD组显示出更多的检索卵细胞和高质量的胚胎.
- 在老鼠中YZD治疗恢复了雌激素水平,减少了卵泡刺激激素,改善了卵巢组织学.
- YZD减少了过度的自细胞形成和脂质积累,这表明自细胞-脂质代谢轴的调节.
结论:
- YZD增强了卵巢储备功能,并改善了患有DOR的妇女的胚胎发育.
- 在接受ART的女性中,YZD可能会增加怀孕潜力.
- 这些发现支持YZD在临床生殖医学中的翻译潜力.
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