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Updated: Jan 9, 2026

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

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核酸上下文模型在预测抗体亲和力成熟时的表现优于蛋白质语言模型.

Mackenzie M Johnson1, Kevin Sung1, Hugh K Haddox1

  • 1Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America.

PLoS computational biology
|December 1, 2025
PubMed
概括

使用核酸语境准确建模体变异 (SHM) 显著改善了对抗体亲和力成熟的预测. 基于核酸的模型在预测B细胞受体演变方面优于先进的蛋白质语言模型.

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