框架集成 工程异对称的氨酸染料用于高性能NIR-II成像和多重标记
Yufei Qin1, Jiaming Guo1, Yujie Qin1
1Center for Advanced Materials Research & Faculty of Arts and Sciences, Beijing Normal University, Zhuhai 519087, P. R. China.
Analytical chemistry
|December 1, 2025
概括
研究人员开发了新的近红外II (NIR-II) 染料,称为AFlavs,用于先进的生物成像. 这些明亮,稳定的光体使得高分辨率,多色的NIR-II成像 in vivo.
科学领域:
- 化学生物学 化学生物学
- 生物医学成像技术 生物医学成像技术
- 有机化学 有机化学
背景情况:
- 开发用于高对比度生物成像的小分子近红外II (NIR-II) 光体存在重大挑战.
- 现有的NIR-II光体通常缺乏先进应用所需的亮度,光稳定性或多重复合能力.
研究的目的:
- 设计和合成一个新的类型的小分子NIR-II光体,以提高生物成像的性能.
- 评估这些新型光体在各种体内成像应用中的性能,包括血管成像和多色成像.
主要方法:
- 集成flavylium和聚甲支架,以创建不对称的NIR-II染料,称为AFlavs.
- 光物理性质的表征,包括亮度,光稳定性和耐灭性.
- 在体内评估AFlav-4用于血管成像,瘤血管评估,缺血-再输血研究和骨定向输送.
- 通过光谱分离分析证明多色成像能力.
主要成果:
- 合成的AFlavs表现出高亮度 (227-2396 M-1 cm-1) 和优越的光稳定性.
- AFlav-4在各种血管成像任务中表现出有效的性能,包括瘤血管干扰和缺血-再输评价.
- AFlavs实现了前所未有的两色,三色和四色多色成像,具有光谱直角性 (>100 nm吸收分离).
结论:
- AFlavs代表了一个有前途的新类小分子NIR-II光体,具有出色的光物理性质.
- 这些染料适用于高分辨率,多色和长期体内NIR-II成像.
- 开发的AFlavs具有促进各种生物医学成像应用的巨大潜力.
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