病毒抑制器AC4被番茄叶卷曲编码的Palampur病毒劫持SA信号以促进病变发生
Abhisha Roy1, Vasundhara Thakur2, Robin Joshi3
1Plant Virology Lab, CSIR-Institute of Himalayan Bioresource Technology (IHBT), Palampur, 176061, Himachal Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, Uttar Pradesh, India.
Plant physiology and biochemistry : PPB
|December 1, 2025
概括
番茄叶卷曲 帕兰普尔病毒 (ToLCPalV) AC4蛋白抑制植物免疫力. 这种双重的贝戈莫病毒蛋白质通过干扰酸 (SA) 信号和运动来破坏系统性获得性抵抗 (SAR).
科学领域:
- 植物病理学 植物病理学
- 分子植物-病毒相互作用
- 植物免疫力 植物免疫力
背景情况:
- 系统性获得耐药性 (SAR) 是植物对病原体的重要防御机制.
- 酸 (SA) 和其衍生物 (MeSA,AzA) 是SAR中的关键移动信号.
- 在单体贝戈莫病毒中已知存在SAR的病毒抑制剂,但它们在双体病毒中的作用尚不清楚.
研究的目的:
- 为了调查番茄叶卷曲Palampur病毒 (ToLCPalV) AC4蛋白在抑制SAR中的作用.
- 探索AC4对SA生物合成和SAR信号运动的影响.
主要方法:
- 对SAR标记基因的定量基因表达概况 (ICS1,PR1).
- 针对SA,MeSA和AzA的有针对性的代谢物测试.
- 在分析中预测蛋白质-蛋白质相互作用和结合部位.
主要成果:
- ToLCPalV AC4蛋白显著降低SAR标记物基因表达和SA,MeSA,AzA水平. 这种蛋白质可以降低SAR标记物基因表达.
- 一种缺乏AC4的突变病毒显示缓解了SAR抑制.
- 在研究表明,AC4和AV2与SA代谢酶和SAR信号相互作用.
结论:
- ToLCPalV AC4蛋白抑制植物SAR,可能是通过干扰SA生产和信号运动.
- 病毒蛋白质AC4和AV2可能会在双分体贝戈莫病毒中充当SAR抑制剂.
- 这项研究为进一步研究病毒操纵植物免疫力的研究提供了基础.
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