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Updated: Jan 9, 2026

Estimation of Telomeric Repeat-containing RNA from DNA/RNA Hybrid Complexes
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Estimation of Telomeric Repeat-containing RNA from DNA/RNA Hybrid Complexes

Published on: December 5, 2025

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用连接体调节TERRA G四复合体:对端粒DNA的影响:RNA杂交体和ALT机制

Federico Dinoi1,2, Simona Marzano3, Maria Ilaria Marino1

  • 1Institute of Molecular Biology and Pathology, National Research Council, Rome 00185, Italy.

Nucleic acids research
|December 1, 2025
PubMed
概括

研究人员确定了新型药物配体,可以稳定TERRA与染色质的结合,从而影响癌细胞中的端粒维护. 这一发现提供了针对端粒功能障碍和替代端粒延长 (ALT) 的新治疗策略.

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