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Updated: Jan 9, 2026

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish
08:09

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Published on: June 7, 2018

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染色体重塑因子CHRAC1通过IRF9/GSDMD/CASP-1调节多克索鲁比诱导的心脏毒性

Tongtong Zang1, Changyi Zhou1, Yue Yu1

  • 1Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, China; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, China; NHC Key Laboratory of Ischemic Heart Diseases, China; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, China; National Clinical Research Center for Interventional Medicine, Shanghai, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

Cellular signalling
|December 1, 2025
PubMed
概括

doxorubicin 诱导的心脏毒性 (DIC) 是癌症治疗的严重副作用. 研究人员发现,表观遗传调节器CHRAC1通过激活IRF9通路来驱动DIC,导致细胞死亡,提供了一个新的治疗点.

关键词:
在CHRAC1中,心脏损伤是因为心脏损伤.卡斯帕塞斯 (Caspase) 是一个德克索鲁比辛是一种多克索鲁比辛.热灭菌的发生.

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