相关实验视频
Updated: Jan 9, 2026

09:12
Nanoparticle-mediated siRNA Gene-silencing in Adult Zebrafish Heart
Published on: July 29, 2018
8.5K
用于生物医学应用的基于Zin的药物输送载体:更新的概述
Puja Nayak1, Shikha Pandey1, Zahid Husain1
1Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, 495009, India.
International journal of biological macromolecules
|December 1, 2025
概括
一种天然的玉米蛋白质Zain显示出作为药物输送和组织工程的生物材料的前景. 它独特的结合性使其能够在药物中进行先进的应用,并创造新的纳米货物.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 制药科学 制药科学
背景情况:
- 来自玉米的蛋白质Zeen因其多功能生物材料特性而闻名.
- 它结合多种分子的能力使其适用于先进的生物医学应用.
- 最近的研究凸显了sian在药物输送和组织工程方面的潜力.
研究的目的:
- 审查作为生物聚合物的基本方面,包括提取和表征.
- 提供基于ain的药物输送系统的最新信息,例如纤维,复合材料,薄膜和微/纳米粒子.
- 探索在药物输送,组织工程和神经科学中扩展的生物医学应用.
主要方法:
- 对油脂提取,表征和修改技术的文献综述.
- 对ain在各种药物输送配方 (纤维,复合材料,薄膜,纳米粒子) 中的使用情况的分析.
- 检查生物医学应用,包括控制药物释放,蛋白质/递送,疫苗递送,基因疗法和组织工程.
主要成果:
- 在生物材料应用中,可以有效地提取和表征Zeen.
- 基于Zain的载体,包括与其他聚合物和填充剂的混合物,在药物输送中表现出有效性.
- 在各种生物医学领域,从向药物输送到组织再生和神经科学,Zain显示出显著的潜力.
结论:
- 泽因是一种有前途的天然生物聚合物,在制药和生物医学领域具有重大潜力.
- 它的适应性允许开发复杂的药物输送系统和先进的组织工程支架.
- 进一步的研究和专利开发强调了在创新的医疗保健解决方案中越来越重要的重要性.
相关概念视频
Drug Delivery: Overview
703
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
703
Bioavailability Enhancement: Drug Permeability Enhancement
176
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
176
Drug Delivery: Miscellaneous Routes
694
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
694
Cellular Membranes and Drug Transport
1.4K
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
1.4K
Carrier-Mediated Transport
981
Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
981
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
184
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
184

