结直肠癌患者的长期空气污染暴露和死亡结果:多中心纵向研究的证据
Chih-Wen Wang1, Pinpin Lin2, Yu-Cheng Chen2
1Department of Computer Science and Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Taiwan; Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Cancer epidemiology
|December 1, 2025
概括
接触细颗粒物 (PM2.5) 和二氧化硫 (SO2) 会增加结直肠癌患者因任何原因死亡的风险. 空气污染和临床阶段的综合影响显著增加了死亡率,突显了减少污染战略的必要性.
科学领域:
- 环境健康 环境健康
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 有限的研究存在于空气污染和结直肠癌死亡率之间的联系在不同的临床阶段.
- 了解这种关系对于公共卫生干预至关重要.
研究的目的:
- 研究暴露于PM2.5和SO2与结直肠癌患者全因死亡率之间的关联.
- 检查临床阶段如何改变这种关联.
主要方法:
- 对5126名结直肠癌患者进行了回顾性队列研究.
- 患者地址的地理编码与空气污染数据 (PM2.5,SO2) 相匹配.
- 使用卡普兰-梅尔和考克斯回归模型进行生存分析,按临床阶段分层.
主要成果:
- 较高的PM2.5和SO2暴露与增加的全因死亡率有关.
- 在0-I和III阶段,PM2.5显示出显著的关联;在II和III阶段,SO2显示出显著的关联.
- 这两种污染物与临床阶段相互作用,联合暴露和阶段类别显示出更高的风险.
结论:
- 升高的PM2.5和SO2水平显著增加了结直肠癌患者的全因死亡风险.
- 风险因临床阶段而异,在早期和后期阶段的影响加剧.
- 减少空气污染暴露对于高风险癌症患者至关重要.
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