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Updated: Jan 9, 2026

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
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一个下一代基于生理学的动力学模型,用于定量化在体外到体内抽取人体中西斯胺诱导的毒性

Kiri G J Romano Olmedo1, Jiaqi Chen1, Ivonne M C M Rietjens1

  • 1Division of Toxicology, Wageningen University and Research, Stippeneng 4, Wageningen 6708 WE, the Netherlands.

Toxicology
|December 1, 2025
PubMed
概括

新的生理基动力学 (PBK) 模型改善了对西斯甲毒性的预测. 这些以人为基础的模型包含活跃的分泌物,为药物开发和患者安全提供更好的风险评估.

关键词:
西斯普拉丁 (Cisplatin) 是一种毒性 毒性 毒性有机离子转运器2 (OCT2)基于生理学的动力学 (PBK) 模型.在体外到体外的定量抽取 (QIVIVE)

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