抗发作药物对儿童患者自主神经系统的影响
Fatemeh Mohammad Alizadeh Chafjiri1, Stephanie Dailey1, Saeid Sadeghian1
1Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Epilepsy research
|December 1, 2025
概括
抗发作药物 (ASM) 可以改变自主神经系统 (ANS) 功能,如心率和温度在患有的儿童. 了解这些影响对于监测治疗疗效和潜在副作用至关重要.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 儿科神经学 儿科神经学
背景情况:
- 服用抗发作药物 (ASM) 的患者经常显示自主神经系统 (ANS) 参数发生变化.
- ANS信号提供了一种潜在的非侵入性方法来监测ASM的应用和有效性.
研究的目的:
- 审查有关ASM对儿科ANS的影响的现有文献.
- 综合关于ASM如何影响心率 (HR),心率变化 (HRV),温度和汗水等生理参数的研究结果.
主要方法:
- 按照PRISMA指南进行系统审查.
- 在PubMed,Web of Science和Embase数据库中搜索到到2024年12月发表的相关研究.
- 选了9837项研究,最终包括23项用于数据提取和分析.
主要成果:
- 尼沙胺和托皮拉与减少出汗和温度升高有关.
- 使用ASM的多疗法导致HRV降低,对酸 (高频) 和巴比他 (低频) 特别有所减少.
- 较高的ASM剂量降低了HRV,而 levetiracetam显示了最小的短期ANS效应,但随着时间的推移改善了副交感控制.
结论:
- ASM可以影响儿科患者的HR,汗水和温度,根据具体的药物和剂量而有不同的影响.
- 了解ASM诱导的ANS变化对于评估药物疗效,识别副作用,以及在预测中考虑混因素至关重要.
- 反映ANS功能的生物信号数据可以帮助开发基于设备的神经调节,检测和预测算法.
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