精神分裂症中的免疫变化和治疗抗体的影响:神经成像研究
Yuya Mizuno1,2,3, Ines Carreira Figueiredo1, Toby Pillinger1,4
1Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
Brain : a journal of neurology
|December 1, 2025
概括
这项研究发现,第一发精神病患者的大脑中18kDa转位蛋白 (TSPO) 水平升高. 虽然纳塔利祖马布治疗适度改善了症状,但它没有改变TSPO水平,这表明TSPO可能不是精神病治疗的直接目标.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫功能障碍与精神分裂症的病理生理学有关.
- 18-kDa转位蛋白 (TSPO) 是神经炎症的标记物,可以通过PET量化.
- 以前的TSPO PET对精神病的研究已经产生了不一致的结果,其可修改性是未知的.
研究的目的:
- 为了比较第一发精神病患者的TSPO基线水平与健康对照.
- 调查纳塔利祖马布治疗是否可以改变精神分裂症患者的TSPO水平和症状.
- 为了确定TSPO是否是精神病中稳定的生物标志物.
主要方法:
- 基线病例控制PET成像使用[18F]DPA-714量化TSPO分布体积比率 (DVR).
- 用纳塔利祖马布或安慰剂治疗三个月的长度研究,随后重复PET成像.
- 使用阳性和阴性综合征量表 (PANSS) 进行症状评估的临床评估.
主要成果:
- 与对照组相比,患有第一发精神病的患者在总和叶灰质中显示出显著更高的TSPO DVR基线.
- 纳塔利祖马布治疗没有显著改变TSPO DVR,尽管穿越了血脑屏障.
- 接受纳塔利祖马布治疗的患者表现出适度的症状改善 (PANSS得分),但没有观察到DVR变化和症状严重程度之间的相关性.
结论:
- 灰质TSPO水平升高存在于第一次精神病发作中.
- 纳塔利祖马布在精神病中的适度临床益处可能无法通过直接降低TSPO来调解.
- 较高的灰质TSPO可能反映非微质细胞表达,TSPO似乎是精神病中稳定的特征生物标志物.
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