内微生物群 瘤微环境重塑 影响 固体瘤免疫疗法
Jiawen Jia1, Wenwen Gao1, Cong Wang1
1Department of Gynecological Oncology Radiotherapy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, China.
Cell death & disease
|December 1, 2025
概括
内微生物群通过重塑瘤微环境来影响癌症免疫疗法的有效性. 准这些微生物有望改善固体瘤治疗反应.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫疗法已经推进了癌症治疗,但固体瘤的应答率仍然很低.
- 瘤微环境 (TME) 极大地影响免疫治疗的疗效.
- 内微生物群越来越多地被认为是TME和治疗反应的关键调节器.
研究的目的:
- 审查内微生物在固体瘤中的作用.
- 探索这些微生物如何影响免疫细胞和TME内的信号传递.
- 讨论微生物群向疗法的潜力,以提高免疫疗法结果.
主要方法:
- 复习多原子分析,确定固体瘤中的细菌特征,包括胰腺管道腺癌 (PDAC).
- 对微生物向治疗的临床前数据的检查.
- 分析内微生物如何与免疫细胞和TME中的信号通路相互作用.
- 研究瘤微卫星状态对微生物影响的影响.
主要成果:
- 细菌特征存在于大量固体瘤中,与治疗耐药性相关的特定联盟.
- 针对微生物群的治疗方法在临床前模型中已经证明有效,增加了瘤清除.
- 内微生物显著影响免疫细胞功能和TME内的信号通路.
- 瘤微卫星状态是瘤内微生物对免疫治疗反应影响的关键决定因素.
结论:
- 内微生物群是固体瘤免疫疗法疗效的关键因素.
- 了解微生物和TME之间的复杂相互作用对于临床翻译至关重要.
- 向瘤内微生物群有可能提高治疗疗效,并预测癌症患者的预后.
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