在一项随机对照试验中,给药途径,预期和对安慰剂的信念的作用与开放标签安慰剂的作用
Michael Schaefer1, Carolin Liedtke2, Sören Enge2
1Medical School Berlin, Rüdesheimer Str. 50, 14197, Berlin, Germany. michael.schaefer@medicalschool-berlin.de.
Scientific reports
|December 1, 2025
概括
开放的安慰剂有效地减少了情绪上的痛苦,没有欺骗. 机制可能涉及无意识的过程,而不是有意识的期望,建议新的治疗途径.
科学领域:
- 心理学 心理学 心理学
- 神经科学是一个神经科学.
- 医学伦理 医学伦理
背景情况:
- 传统的安慰剂使用通常涉及欺骗.
- 新兴研究表明,开放标签安慰剂 (OLP) 可以在没有欺骗的情况下有效.
- OLP的基本机制仍然不清楚,特别是预期的作用.
研究的目的:
- 调查开放标签安慰剂效应背后的机制.
- 检查给药途径,预期和信念对OLP疗效的影响.
- 探索预期是否是OLP效应的关键驱动因素,就像隐藏的安慰剂一样.
主要方法:
- 健康的参与者看了令人痛苦的图像.
- 参与者接受了开放标签安慰剂或是控制组.
- 关于给药途径,治疗预期和信念的研究安慰剂效应.
主要成果:
- 开放式注射安慰剂显著降低了参与者的情绪困扰.
- 服用途径对安慰剂反应没有影响.
- 预期的治疗时间没有预测实际的安慰剂效应,但与自我报告的效应强度相关.
结论:
- 开放式的安慰剂在减少情绪痛苦方面是有效的,即使是诚实地使用.
- 相信安慰剂,不一定是有意识的期望,似乎与效应的强度有关.
- OLP机制可能主要是无意识地运作,挑战传统模型.
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