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AttBiLSTM_DE:使用词嵌入和基于注意力的优化BiLSTM框架来增强抗癌预测.
Most Jebun Nahar Juthy1,2, S M Hasan Mahmud3,4, Md Faruk Hosen5,6
1Department of ICT, Mawlana Bhashani Science and Technology University (MBSTU), Santosh, 1902, Tangail, Bangladesh.
Scientific reports
|December 1, 2025
概括
这项研究介绍了AttBiLSTM_DE,一个使用深度学习的计算框架,用于准确预测抗癌 (ACP). 这种人工智能驱动的方法加速了新型癌症治疗方法的发现,改善了患者的治疗结果.
科学领域:
- 计算生物学是一种计算生物学.
- 生物信息学是一种生物信息学.
- 药物发现 药物发现
背景情况:
- 在全球范围内,癌症是导致死亡的首要原因,目前的治疗方法会导致显著的副作用.
- 抗癌 (ACP) 对向癌症治疗有希望,但实验性鉴定是昂贵和耗时的.
研究的目的:
- 为准确预测抗癌 (ACP) 开发一个先进的计算框架.
- 克服试验查新型ACP的局限性.
- 帮助开发新的癌症治疗方法和药物发现.
主要方法:
- 利用自然语言处理 (NLP) 技术 (一热编码,GloVe,fastText,Word2Vec) 和k-mer嵌入用于序列表示.
- 开发了一个差异演化 (DE) 算法,用于特征优化和权重赋值.
- 采用基于注意力的双向长期短期记忆 (BiLSTM) 模型进行增强的预测.
主要成果:
- AttBiLSTM_DE模型实现了95.85%的高预测准确度和98.48%的曲线下面积 (AUC).
- 优于现有的以注意力为基础的深度学习模型在预测ACP方面的表现.
- 证明了框架在识别潜在的抗癌的有效性.
结论:
- 该AttBiLSTM_DE框架提供了一个强大的和高效的计算工具,用于ACP预测.
- 这种方法可以显著加速新型抗癌的发现,用于治疗开发.
- 可访问的在线网络服务器可用于实时的ACP预测.
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