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Updated: Jan 9, 2026

Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol
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在温和条件下进行化物化[18F]的简化,强大的协议,以增强晚期芳香放射性化物

Stefan Milton1,2,3, Alexandros Pappas1,2,3, Niki Constantinou1

  • 1Clinical Neuroscience, Karolinska Institute, Visionsgatan 4, Stockholm, 17164, Sweden.

Scientific reports
|December 1, 2025
PubMed
概括

这项研究引入了一种使用弱离子交换盒直接放射性化的新方法,提高了对基敏感PET前体的放射化学转换和产量. 这一进步提高了关键的无线电追踪器的可访问性,用于患者护理.

关键词:
18F 18F 18F 18F 18F 18F 18F 18F 18F 18F 18F 18F 18F 18F基础 基础 基础 基础 基础化 化 化 化放射性化是一种放射性化.泰特拉辛 (tetrazine) 是一种四氨酸.陷 陷 是一个陷.

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Bromination and chlorination of aromatic rings by electrophilic aromatic substitution reactions are easily achieved, but fluorination and iodination are difficult to achieve. Fluorine is so reactive that its reaction with benzene is difficult to control, resulting in poor yields of monofluoroaromatic products. To address this, Selectfluor reagent is used as a fluorine source in which a fluorine atom is bonded to a positively charged nitrogen.
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