肝纤维化指数和与代谢功能障碍相关的脂肪性肝病的死亡率:韩国队列研究
1Department of Occupational and Environmental Medicine, Medical Support Division, Pyeongchang County Public Health Clinic, Seoul, Gangwon-do, Korea.
Scientific reports
|December 1, 2025
概括
通过年龄调整的FIB-4指数测量较高的肝纤维化,增加了代谢功能障碍相关的脂肪性肝病 (MASLD) 患者的死亡风险. 这一发现突出了FIB-4的发现.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 心血管医学 心血管医学
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题.
- 与MASLD相关的长期死亡风险,特别是肝纤维化,在一般人群中尚未完全理解.
- 现有的风险评估可能无法充分捕捉MASLD中肝纤维化的预后价值.
研究的目的:
- 通过年龄调整的Fibrosis-4 (FIB-4) 余量指数量化的肝纤维化与MASLD患者的死亡率之间的关联.
- 为了确定FIB-4指数是否能够预测所有原因和心血管死亡率,而不考虑其他风险因素.
主要方法:
- 在韩国 (2002-2022) 进行了一项对134,686名被诊断为MASLD的成年人的队列研究.
- 肝纤维化被评估使用年龄调整的FIB-4残留指数,该指数来自常规血液检测和年龄.
- 考克斯的比例危险模型分析了FIB-4指数和死亡结果之间的关联,并对多个共同变量进行了调整.
主要成果:
- 较高的年龄调整FIB-4指数显著与所有原因死亡率 (HR 1.489) 和心血管死亡率 (HR 1.478) 的风险增加有关.
- 在调整了社会人口统计学,行为和临床因素后,这些关联仍然很重要.
- 与心血管疾病死亡率的关联在39岁以上的个体中尤为明显.
结论:
- 根据年龄调整的FIB-4指数是MASLD患者全因和心血管死亡率增加的独立预测指标.
- 使用FIB-4指数的肝纤维化评估提供了超越传统心脏代谢风险因素的宝贵预后信息.
- 这种非侵入性标记物可以帮助对患有MASLD的患者进行风险分层和管理.
相关概念视频
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
169
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
169
Ultrasound II: Endoscopic Ultrasound and FibroScan
506
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
506
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
203
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
203
Liver Regeneration
4.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.2K


