在宏观新生儿大脑网络中的动态结构-功能合.
Zhe Zhang1,2,3, Chi Zhang1,3, Xinlin Zhang1,3
1Institute of Brain Science and Department of Physiology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China.
Communications biology
|December 1, 2025
概括
新生儿大脑发育涉及动态结构-功能合 (SFC),随着年龄的增长而成熟,特别是在默认模式网络 (DMN) 中. 过早出生的婴儿显示SFC减少,突出显示了他们对早期逆境的脆弱性.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 医疗成像医学成像
背景情况:
- 新生儿时期对于大脑发育至关重要,但结构变化和功能重组之间的联系尚不清楚.
- 了解大脑网络如何成熟对于识别发育轨迹和脆弱性至关重要.
研究的目的:
- 描述新生儿大脑中的动态结构功能合 (SFC).
- 调查SFC,皮层微观结构和网络灵活性之间的关联.
- 为了比较SFC在按期出生的婴儿和早产婴儿.
主要方法:
- 利用399名新生儿的多模态MRI数据 (348名满期出生,51名早产).
- 在宏观大脑网络中分析了动态SFC.
- 通过T1w/T2w比率评估皮质微结构,并测量网络灵活性.
主要成果:
- 动态SFC在新皮层中各不相同,并且随着月经后年龄的增加而增加,特别是在默认模式网络 (DMN) 中.
- 后部DMN动态SFC调解T1w/T2w比率和网络灵活性之间的关系.
- 与按期出生的婴儿相比,早产婴儿的SFC动态显著减少,DMN发育发生改变.
结论:
- 动态SFC是新生儿大脑成熟的潜在生物标志物.
- 研究结果提供了关于内部定向认知的早期发展的见解.
- 早产婴儿的DMN发育变化可能与子宫外暴露和生命早期的逆境有关.
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