沙门氏甲型病毒的伤寒毒素在急性伤寒发烧期间引起宿主抗菌反应
Salma Srour1, Francesca K Brown1, James W Sheffield1
1School of Bioscience, University of Sheffield, Sheffield, UK.
EMBO molecular medicine
|December 1, 2025
概括
这种类型的沙门氏菌.
科学领域:
- 微生物学和免疫学
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 沙门氏菌Typhi分泌伤寒毒素,在伤寒发烧期间激活DNA损伤反应 (DDR).
- 毒素抑制人类沙门氏菌菌病的机制尚不清楚.
- 伤寒热的宿主-病原体相互作用需要进一步阐明.
研究的目的:
- 为了研究在沙门氏菌 Typhi 感染期间宿主血蛋白质组的变化.
- 阐明宿主抗菌因子在抑制细菌血症中的作用.
- 了解伤寒毒素,DNA损伤反应和宿主防御之间的相互作用.
主要方法:
- 来自细菌性参与者的血的定量蛋白质组分析.
- 在实验室中使用复合型伤寒毒素和沙门氏菌感染在培养细胞中的研究.
- 评估溶酶 (LYZ) 功能,p53调节和氧化应激反应.
主要成果:
- 沙门氏菌感染和伤寒毒素诱导了酶 (LYZ) 和阿波利波蛋白C3 (APOC3) 的分泌.
- LYZ表现出抗菌性质,抑制沙门氏菌的生长和毒性.
- LYZ分泌与ATM/ATR依赖的DNA损伤反应 (DDR) 和p53介导的细胞衰老有关.
结论:
- 伤寒毒素诱导的DDRs触发宿主抗菌反应,包括LYZ分泌.
- 赖索酶在抑制沙门氏菌在伤寒期间的细菌血症方面发挥着至关重要的作用.
- 这些发现揭示了一种新型宿主防御机制,以抵御沙门氏菌 Typhi 感染.
相关概念视频
Defense Against Bacterial Pathogens
2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K
Stringent Response in E. coli
267
Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
267
Humoral Immune Responses
83.2K
Overview
83.2K
Antimicrobial Proteins
12.9K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
12.9K
Transduction
1.1K
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
1.1K
Other Stress Responses in Bacteria
314
Bacteria have global regulatory systems that control several types of stress mechanisms. These include Pho regulon and the heat shock response, which are essential systems for environmental adaptation, such as nutrient limitation and proteotoxic stress. The Pho regulon and the heat shock response exemplify bacterial resilience, enabling rapid adaptation to fluctuating environmental conditions.Pho RegulonBacteria require phosphorus for essential cellular processes, including nucleic acid...
314


